When, for whom, which variants… What we all know concerning the new vaccines in opposition to Covid-19

When, for whom, which variants… What we all know concerning the new vaccines in opposition to Covid-19

Covid-19 contaminations have been growing once more in France for 2 weeks, suggesting a potential eighth wave of the epidemic on the finish of the summer time, the extent of which stays troublesome to foretell.

These new so-called bivalent vaccines, that’s to say that they comprise the messenger RNA of the unique Sars-CoV-2 virus and messenger RNA particular to the variant, are anticipated with the hope of getting higher shields. in opposition to the virus.

This is what you’ll want to know.

What variants?

For brand new injections, the HAS recommends, “ideally”, “one of many three bivalent vaccines” – two developed by Pfizer/BioNTech and the third by Moderna – just lately validated by the European Medicines Company. This advice applies whatever the vaccine initially administered to the individual.

These sera, which use messenger RNA expertise like nearly all of the vaccines used till now, “should not new vaccines however vaccines tailored to circulating strains”underlined the HAS, drawing a parallel with the flu vaccines.

These are the vaccines from Moderna and Pfizer/BioNTech focusing on the unique pressure of the virus and the BA.1 variant of Omicron, and the vaccine from Pfizer/BioNTech focusing on the unique pressure and the BA subvariants .4 and BA.5 from Omicron.

Omicron and its sub-variants have been dominant all through 2022, dethroning earlier Alpha and Delta variants. The BA.4 and BA.5 subvariants are notably answerable for a brand new wave in Europe and america in current months.

The opinion of the HAS, initially anticipated in early September, had been postponed to know all the suggestions of the European regulator. He was taken “on the idea of the accessible knowledge and in an epidemic context marked by the bulk circulation of the BA.5 sub-variant”clarified the HAS.

In comparison with the unique vaccines, “the anticipated medical efficacy of those new bivalent vaccines is a minimum of equal and even superior” and their tolerance is “an identical”, in accordance with HAS.

Along with Moderna and Pfizer/BioNTech, different bivalent vaccines are within the pipeline. That is significantly the case of a vaccine candidate from the French and British laboratories Sanofi and GSK focusing on the Delta and Beta strains.

For who?

Two classes are focused for the brand new dose: these over 60 and people beneath 60 susceptible to a extreme type of Covid-19 (individuals with comorbidities, pregnant ladies, immunocompromised individuals, youngsters and adolescents at excessive threat).

The entourage of those individuals in danger and professionals within the well being and medico-social sector are additionally involved.


Anticipating the restart of the epidemic, with a brand new wave of “magnitude” unsure, the Minister of Well being talked about on the finish of August “a vaccination marketing campaign which is able to resume within the fall”.

“The Ministry of Well being and Prevention will be aware of the opinion of the HAS, as because the begin of the well being disaster, and can resolve on the vaccination technique to be applied on the idea of the suggestions”stated Tuesday the cupboard of François Braun.

The brand new vaccines, of which the nation has already ordered a number of million, ought to be rapidly accessible in vaccination facilities and pharmacies.

Orders from the Sanofi (monovalent Beta) and Spanish Hipra (bivalent Alpha-Beta) laboratories, whose vaccines are nonetheless being studied by the European Medicines Company, have additionally been positioned, however should not anticipated earlier than the top of the yr, in accordance with the Directorate Common of Well being.

“Instantly and since the variety of instances of infections has began to rise once more for a number of days”these most in danger are invited to not wait to obtain their second booster in the event that they haven’t but had it, remembers the HAS.

Regardless of the suggestions, solely about 30% of individuals over 60 acquired a second booster dose. Nonetheless, the unique model of the vaccine remains to be efficient in stopping severe types, hospitalizations and deaths related to the illness, hammer the well being authorities. And it’s the just one potential for a primary vaccination.

And the flu?

For this new reminder marketing campaign, the HAS maintains its advice to couple it with the annual flu vaccination, which is able to begin on October 18.

A concomitant injection or the identical day of the 2 vaccines is feasible.

#variants.. #vaccines #Covid19

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