“We have to gather the stools of 100,000 individuals for microbiota mapping”

“We have to gather the stools of 100,000 individuals for microbiota mapping”

“Present me your microbiota, I am going to inform you for those who’re wholesome. And if you’ll stay so. Now known as the second mind, our intestinal microbiota is a real reflection of our common state of well being. Composed of billions of micro organism, nonetheless, it has not revealed its many secrets and techniques. And that is what Le French Intestine, a analysis undertaking led by INRAE ​​and carried out in collaboration with AP-HP, will attempt to pierce.

The target: “Mapping the intestinal microbiota in France to higher outline its composition, explains to 20 minutes Joël Doré, analysis director specializing in microbiota at INRAE ​​and scientific coordinator of French Intestine. And analyze the hyperlink between its variations and the event of sure illnesses”. However to attain this, scientists want matter. They’re thus launching an enchantment for donations aimed toward gathering “a stool pattern and the dietary and medical information of 100,000 volunteers over the following 5 years”, continues Joël Doré, who has been finding out the microbiota for greater than forty years. He responds to 20 minutes.

Why does the French Intestine want stool samples from 100,000 people? Why a lot?

Data of the microbiota has progressed enormously over the previous twenty years. And at this time, in the identical manner that we discovered to sequence the human genome, we’re endeavor the sequencing of all of the genes and microorganisms that make up our intestinal microbiota. We’re microbial beings, with a microbiota in our intestines, lungs, urogenital sphere or pores and skin. We’re in fixed interplay with 50,000 billion micro organism and microbes.

And the intestinal microbiota is in dialogue with our whole physique. Nonetheless, we nonetheless have loads to find about it, or slightly about them: we’ve got been capable of observe that within the common inhabitants in good well being, there’s a slightly unimaginable heterogeneity of the intestinal microbiota, with nearly as many distinctive microbiotas as people. . This constructing information must be backed up by a really broad baseline.

The French Intestine is a singular undertaking, open to people in good well being, but additionally in collaboration with docs to combine cohorts of sufferers with continual illnesses, as a way to have a consultant panel. This includes finding out the function of meals, air pollution and a set of things on the microbiota.

This undertaking goals specifically to mannequin and predict modifications within the intestinal microbiota related to illnesses. Does this imply that having a weak or unbalanced microbiota paves the best way for the event of sure pathologies?

Completely ! The incidence charge of pathologies in our trendy societies has exploded for 3 generations, with out our having any management. Nonetheless, the microbiota performs a vital function: whether it is wholesome, it could actually represent a protecting defend towards a spread of illnesses. However whether it is weak or in dysbiosis, it could actually trigger intestinal permeability, which is able to generate irritation, oxidative stress and decrease immunity.

A vicious circle then begins which makes the microbiota an element favoring the event of many continual illnesses: IBD (inflammatory bowel illness), metabolic illnesses similar to diabetes or weight problems, but additionally sure cancers and lots of of neurological illnesses.

One of many axes of the French Intestine will thus deal with the research of the hyperlink between intestinal microbiota and continual illnesses, but additionally neuro-developmental problems similar to autism, schizophrenia and bipolarity, or with neurodegenerative illnesses similar to Parkinson’s. .

By finishing up this mapping of the microbiota, can we hope to make it a well being prevention software? Even a drug?

This undertaking goals to develop analysis and therapeutic optimization: the microbiota could be a predictive software. Within the therapy of most cancers, it has been demonstrated that sure weak or unbalanced microbiota are predictive of the non-response to immunotherapy. Within the discipline of weight problems, sufferers with a very depleted microbiota will usually fail to manage their weight, enhance their irritation or scale back their signs of diabetes.

This subsequently means that there’s a part of therapeutic innovation to be developed: we can use the microbiota both as a lever or as a sort of medication. We predict we will go so far as the method of transferring microbiota from a wholesome particular person to a sick particular person to rework a affected person who doesn’t reply to a therapy right into a responder.

We will subsequently suppose that within the face of sure illnesses, making an allowance for the part of the intestinal microbiota may result in extra effectivity and efficiency in therapeutic approaches. It is hypothetical, even when there are already a couple of areas during which that is progressing. That is already a actuality within the discipline of the combat towards IBD, similar to Crohn’s illness or ulcerative colitis, the place the switch of faecal microbiota from a wholesome particular person permits the transplanted affected person to rebuild an intestinal microbiota by symbiosis. It acts like a drug, with an amazing enchancment within the signs of the illness.

How can we act on the standard of our microbiota? And the way can everybody make their “contribution” to science?

The French Intestine goals to maneuver in direction of customized preventive vitamin, to supply suggestions to make sure or restore a microbiota whose composition, richness and variety make it extra favorable to the upkeep of excellent well being, to make a continual illness prevention mechanism. As a result of every little thing is linked: microbiota and immune system are mirrors that consistently work together.

Everybody can contribute by answering our name for donations. It is fairly taboo to ask individuals to self-collect a stool pattern. However most people’s curiosity within the microbiota has created a craze. And it is quite simple, you simply need to be of authorized age and go to our LeFrenchGut website, examine your eligibility (not having taken a ‘antibiotics lately) and full a fifteen-minute questionnaire, earlier than receiving a self-collection package to be returned by put up in a stabilization liquid. The pattern shall be subjected to sequencing, and can be a part of our reference base.

The French Intestine is a part of a global undertaking, the “Million microbiomes of people”, which goals to map a million human microbiota and construct the biggest database on the earth.

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