A related polypill in secondary post-infarction prevention

A related polypill in secondary post-infarction prevention

Why is that this vital?

Polypills, or fastened combos, simplify remedy and may promote higher compliance. Different research have already proven the good thing about fastened combos in major prevention. Their usefulness in secondary prevention have to be confirmed.


This section 3 scientific research, randomized and managed, was carried out in 113 European facilities (Spain, Italy, France, Germany, Poland, Czech Republic, Hungary). Recruited sufferers needed to have had a myocardial infarction within the 6 months previous inclusion and needed to be over 75 years previous or a minimum of 65 years previous with a further danger issue (diabetes, renal failure, historical past of IDM , coronary revascularization or stroke). They have been randomized between the polypill and the traditional remedy. Medical follow-up was supplied for as much as 24 months and phone follow-up for as much as 48 months. The affected person’s adherence to remedy and the incidence of main cardio or cerebrovascular occasions have been assessed.

Precept outcomes

A complete of two,499 sufferers have been randomized (imply age 76.0 years, 31.0% feminine, 77.9% hypertensive, 57.4% diabetic, 51.3% smoking historical past). Imply systolic blood strain (SBP) was 129.1mmHg and imply LDL-c stage was 89.2mg/dL.

On the finish of a median period of follow-up of 36 months, a significant occasion occurred in 9.% and in 12.7% of the polypill and common care teams respectively, a hazard ratio favorable to the fastened mixture (0 .76 [0,60 -0,96]p=0.02). The incidence of dying from any trigger or of an hostile occasion (haemorrhage, renal failure, allergy to remedy, discontinuation of remedy) involved 8.2% of these on polypill and 11.7% of these on common care (HR0.70 [0,54 -0,90]p=0.005).

The frequency and nature of hostile occasions have been comparable between the teams.

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