the amount of viral antigen is related to the severity of the disease
THE ESSENTIAL
- One in eight people have the after-effects of their Covid-19 infection, in particular respiratory, abdominal or even muscular pain.
- This Tuesday, August 30, nearly 15,000 patients are being hospitalized, including 850 in critical care.
- One in eight people have the after-effects of their Covid-19 infection, in particular respiratory, abdominal or even muscular pain.
According to a new study published in the Annals of Internal Medicine, people hospitalized with an acute infection with SARS-CoV-2, the virus that causes Covid, have a higher level of viral antigen in the blood than other patients with the disease. coronavirus. The average antigen level against SARS-CoV-2 is 3.10 times higher in patients requiring non-invasive ventilation or high-flow oxygen therapy (both breathing aid techniques).
The measurement of antigens, a promising means
Other factors are also correlated on a lesser scale, with a higher level of antigen: male sex, shorter time after hospital admission, reduction in the number of days of treatment with Remdesivir and the ‘renal failure. On the other hand, skin color, ethnic origin, body mass index and immunosuppression have no consequences.
The authors suggest that the levels of antigen against SARS-CoV-2 would be promising biomarkers (substance which serves as a measuring tool) to predict the progression of the disease in a patient hospitalized for Covid. They could also help to better understand the development of the disease.
More than 2,500 attendees
To reach this conclusion, the researchers took blood samples from more than 2,500 participants from ten countries, from August 2020 to November 2021. All were adults hospitalized with acute SARS-CoV-2 infection, with more or less 12 days of symptoms, enrolled in the Kirby Institute’s TICO (Therapeutics for Inpatients with Covid19) trial platform.
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